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Pharmaceuticals Industry 99.9% Purity Industrial Solvent Ethyl Acetate factory price CAS No 141-78-6

Product name: Ethyl Acetate
CAS: 141-78-6
MF: C4H8O2
MW: 88.11
EINECS:205-500-4
MDL Number:MFCD00009171
 
  • 99.9%

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Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements: CodeHazard statementsHazard classCategorySignal wordPictogramP-CodesH225Highly Flammable liquid and vapourFlammable liquidsCategory 2DangerP210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501H319Causes serious eye irritationSerious eye damage/eye irritationCategory 2AWarningP264, P280, P305+P351+P338,P337+P313PH336May cause drowsiness or dizzinessSpecific target organ toxicity,single exposure; Narcotic effectsCategory 3WarningP261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements: P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.P233Keep container tightly closed.P261Avoid breathing dust/fume/gas/mist/vapours/spray.P280Wear protective gloves/protective clothing/eye protection/face protection.P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.P370+P378In case of fire: Use … for extinction.

Properties


Melting point :−84 °C(lit.)
Boiling point :76.5-77.5 °C(lit.)
Density :0.902 g/mL at 25 °C(lit.)
vapor density :3 (20 °C, vs air)
vapor pressure :73 mm Hg ( 20 °C)
refractive index : n20/D 1.3720(lit.)
FEMA : 2414 | ETHYL ACETATE
Flash point :26 °F
storage temp. :Store at +2°C to +25°C.
solubility :Miscible with ethanol, acetone, diethyl ether and benzene.
pka :16-18(at 25℃)
form :Liquid
Specific Gravity :0.902 (20/20℃)
color :APHA: ≤10
Relative polarity :0.228
Odor :Pleasant fruity odor detectable at 7 to 50 ppm (mean = 18 ppm)
explosive limit :2.2-11.5%, 38°F
Odor Threshold :0.87ppm
Odor Type :ethereal
Water Solubility :80 g/L (20 ºC)
λmax :λ: 256 nm Amax: ≤1.00
λ: 275 nm Amax: ≤0.05
λ: 300 nm Amax: ≤0.03
λ: 325-400 nm Amax: ≤0.005 JECFA Number :27
Merck :14,3757
BRN :506104
Henry's Law Constant :0.39 at 5.00 °C, 0.58 at 10.00 °C, 0.85 at 15.00 °C, 1.17 at 20.00 °C, 1.58 at 25.00 °C (column stripping-UV, Kutsuna et al., 2005)
Exposure limits :TLV-TWA 400 ppm (~1400 mg/m 3) (ACGIH, MSHA, and OSHA); IDLH 10,000 ppm (NIOSH).
Dielectric constant :23.0(Ambient)
Stability :Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
InChIKey :XEKOWRVHYACXOJ-UHFFFAOYSA-N
LogP :0.68-0.73 at 20-25℃
CAS DataBase Reference : 141-78-6(CAS DataBase Reference)
NIST Chemistry Reference : Ethyl acetate(141-78-6)
EPA Substance Registry System : Ethyl acetate (141-78-6)




Description

Ethyl acetate is widely used as a solvent in cleaning of the circuit board. It is most suited for HPLC instruments and spectrophotometers including the UV-visible spectrophotometer, the IR spectrometer and the mass spectrometer. In addition, it can also be used as a solvent in column chromatography and solvent extraction. It is also used in glues, nail polish removers, decaffeinating tea and coffee and in cigarettes. It is present in confectioneries, perfumes and fruits.


CERTIFICATE OF ANALYSIS


Commodity

Ethyl Acetate

Standard

GB/T3728-2007

Items

Index


Result


Superior

First-grade

Qualified


Appearance

Transparent liquid, no suspended impurities

Qualified

Chromaticity/Hazen,(Pt-Co)  ≤

10

10

Density (20℃)/(g/ ㎝ 3)

0.897~0.902

0.901

Ethyl acetate % ≥

99.9

99.5

99.2

99.9

Ethanol    %  ≤

0.04

0.20

0.40

0.001

Water    %    ≤

0.05

0.10

0.15

0.01

Acidity(as acetic acid)%  ≤

0.004

0.005

0.003

Distillation range℃(at 0℃, 101.3kpa)


76.0~78.0


75.5~78.0


76.1~77.8

Evaporation residue %  ≤

0.001

0.002

0.001


Ethyl Acetate Packaging Information

Ethyl acetate packaging

Capacity

20GP

40GP

drum

180 kg /drum

total 80 drums, Net 14.4 ton

total 140 drums, Net 25.2 ton

Ethyl Acetate Appacition In Pharmaceuticals Industry

In the pharmaceutical industry, ethyl acetate serves multiple roles, notably:

· Solvent for Extractions: Used in the extraction and purification of antibiotics, certain vitamins, and other active pharmaceutical ingredients (APIs).

· Intermediate: In the synthesis of various drugs, ethyl acetate acts as a key solvent or reactant.

· Coating Agent: Employed in coating formulations for pills and tablets to ensure controlled release of the drug.



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